A-485 is a potent and selective HAT inhibitor of p300/CBP in vitro with an IC50 of 10 nM in a p300 TR-FRET assay and 3 nM in a CBP TR-FRET assay with selectivity > 1000-fold over closely related HATs.
A-485 is a potent and selective HAT inhibitor of p300/CBP in vitro with an IC50 of 10 nM in a p300 TR-FRET assay and 3 nM in a CBP TR-FRET assay with selectivity > 1000-fold over closely related HATs.
A-582941 dihydrochloride is a potent, selective, partial agonist of α7 nAChR across the blood-brain barrier, with Ki values of 10.8 nM in rat meninges and 16.7 nM in human frontal cortex.Additionally, A-582941 dihydrochloride binds to human 5- and 5HT3 receptors with a Ki value of 150 nM. In addition, A-582941 dihydrochloride can bind to human 5- HT3...
A-582941 dihydrochloride is a potent, selective, partial agonist of α7 nAChR across the blood-brain barrier, with Ki values of 10.8 nM in rat meninges and 16.7 nM in human frontal cortex.Additionally, A-582941 dihydrochloride binds to human 5- and 5HT3 receptors with a Ki value of 150 nM. In addition, A-582941 dihydrochloride can bind to human 5- HT3...
A-582941 dihydrochloride is a potent, selective, partial agonist of α7 nAChR across the blood-brain barrier, with Ki values of 10.8 nM in rat meninges and 16.7 nM in human frontal cortex.Additionally, A-582941 dihydrochloride binds to human 5- and 5HT3 receptors with a Ki value of 150 nM. In addition, A-582941 dihydrochloride can bind to human 5- HT3...
A-582941 dihydrochloride is a potent, selective, partial agonist of α7 nAChR across the blood-brain barrier, with Ki values of 10.8 nM in rat meninges and 16.7 nM in human frontal cortex.Additionally, A-582941 dihydrochloride binds to human 5- and 5HT3 receptors with a Ki value of 150 nM. In addition, A-582941 dihydrochloride can bind to human 5- HT3...
A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM.
A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM.