A-582941 dihydrochloride

A-582941 dihydrochloride is a potent, selective, partial agonist of α7 nAChR across the blood-brain barrier, with Ki values of 10.8 nM in rat meninges and 16.7 nM in human frontal cortex.Additionally, A-582941 dihydrochloride binds to human 5- and 5HT3 receptors with a Ki value of 150 nM. In addition, A-582941 dihydrochloride can bind to human 5- HT3 receptors at a Ki value of 150 nM. A-582941 dihydrochloride can be used in studies of various neurodegenerative diseases and cognitive deficits.