BI-0115 inhibits the C-type lectin family member lectin-like oxidized LDL-receptor-1 (LOX-1) by stabilizing an inactive tetrameric form of the protein.
YHO-13177 is a potent and specific inhibitor of breast cancer resistance protein (BCRP/ABCG2).
Trofinetide (NNZ-2566) acetate is a novel analogue of the amino-terminal tripeptide of IGF-1, stimulates synaptic maturation, inhibits the production of inflammatory cytokines and the hyperactivation of microglia and astrocytes, and increases the amount of available IGF-1 that can bind to the IGF-1 receptor. Sequence: G-α-Me-Pro-E.
SB-743921 is a highly potent and active KSP inhibitor with a Ki of 0.1 nM for KSP (Eg5).
OSS_128167 is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.
ISO-1, also known as MIF Antagonist, is a MIF inhibitor with an IC50 of 7 uM. ISO-1 exerts anti-cancer effects on PANC-1 cell proliferation, migration and invasion in vitro, and inhibited PANC-1 cell-induced tumour growth in xenograft mice in vivo.
Rigosertib sodium is a dual non-ATP inhibitor of polo-like kinase 1 (Plk1) and phosphoinositide 3-kinase pathways (PI3K).
Zinc Protoporphyrin is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor.