E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interactions in vitro. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling.
N-hexanoyl-l-homoserine lactone is a short-chain N-acyl-homoserine lactone (AHL). AHL is an intercellular communication signal molecule in the quorum-sensing system of Gram-negative bacteria and mediates information exchange between eukaryotic plants and prokaryotic bacteria.
E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interactions in vitro. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling.
A939572 is a potent, orally active stearyl CoA desaturase 1 SCD1 inhibitor that acts on mSCD1 and hSCD1 with IC50
A939572 is a potent, orally active stearyl CoA desaturase 1 SCD1 inhibitor that acts on mSCD1 and hSCD1 with IC50
2' -deoxy-5-formylcytidine is an effective internal triplet photosensitizer in DNA. 2' -deoxy-5-formylcytidine can be used as a new hot spot for DNA photodamage.
2' -deoxy-5-formylcytidine is an effective internal triplet photosensitizer in DNA. 2' -deoxy-5-formylcytidine can be used as a new hot spot for DNA photodamage.
NVP-CGM097 is a highly effective and selective MDM2 inhibitor with a Ki value of 1.3 nM.
GeA-69 is a cell-penetrating selective allosteric inhibitor targeting Macrodomain 2 (MD2) with a Kd of 2.1 µM.
C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity.
C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity.
G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with Kis of 3.7 nM and 11 nM for PAK1 and PAK2, respectively.