Sulanemadlin (ALRN-6924) is a stapled peptide that blocks interactions between p53 and both MDM2 and MDMX.
Flavokawain A is an anticarcinogenic agent, a chalcone found in kava extracts with antitumor activity. Flavokawain A induces apoptosis through Bax protein-dependent and mitochondrial-dependent apoptosis pathways. Flavokawain A has the potential to be used in bladder cancer related research.
Flavokawain A is an anticarcinogenic agent, a chalcone found in kava extracts with antitumor activity. Flavokawain A induces apoptosis through Bax protein-dependent and mitochondrial-dependent apoptosis pathways. Flavokawain A has the potential to be used in bladder cancer related research.
Flavokawain B (Flavokavain B) is a chalcone isolated from the root extract of kava drunken pepper and is an effective apoptotic inducer that inhibits the growth of various cancer cell lines. (Flavokavain B) has strong anti-angiogenic activity. (Flavokavain B) inhibits the migration and vascular formation of human brain endothelial cells (HUVEC) at very...
Flavokawain A is an anticarcinogenic agent, a chalcone found in kava extracts with antitumor activity. Flavokawain A induces apoptosis through Bax protein-dependent and mitochondrial-dependent apoptosis pathways. Flavokawain A has the potential to be used in bladder cancer related research.
Ly-3475070 is the first oral bioavailable, selective and extracellular enzyme CD73 (cluster of Differentiation 73, 5'-ecto-nucleotidase, 5' -nt, Ecto -5'-nucleotidase) inhibitor.
Ly-3475070 is the first oral bioavailable, selective and extracellular enzyme CD73 (cluster of Differentiation 73, 5'-ecto-nucleotidase, 5' -nt, Ecto -5'-nucleotidase) inhibitor.
Neriifolin, a cardiac glycoside that penetrates the central nervous system, is a typeNa, K-ATPase++ of inhibitors. Neriifolin targets beclin 1, inhibits the formation of LC3-associated phagosomes, and improves the development of experimental autoimmune encephalomyelitis (EAE).
Neriifolin, a cardiac glycoside that penetrates the central nervous system, is a typeNa, K-ATPase++ of inhibitors. Neriifolin targets beclin 1, inhibits the formation of LC3-associated phagosomes, and improves the development of experimental autoimmune encephalomyelitis (EAE).
NVP-BSK805 is a potent, selective, ATP competitive JAK2 inhibitor with an IC50 of 0.5 nM, which is more than 20 times more selective than acting on JAK1, JAK3 and TYK2.
NVP-BSK805 is a potent, selective, ATP competitive JAK2 inhibitor with an IC50 of 0.5 nM, which is more than 20 times more selective than acting on JAK1, JAK3 and TYK2.
E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interactions in vitro. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling.