Linderalactone is an important sesquiterpene lactone isolated from Radix Linderae. Linderalactone inhibits cancer cell growth by regulating the expression of apoptosis-related proteins and inhibiting the JAK/STAT signaling pathway. Linderalactone also inhibited the proliferation of lung cancer A-549 cells with an IC50 value of 15 µM.
Cucurbitacin S is isolated from cucurbitaceae, the cucurbitaceae family, and has anti-cancer and anti-inflammatory properties.
Lucifer Yellow CH dilithium salt is a highly fluorescent dye that is useful in marking nerve cells. Lucifer Yellow CH dilithium salt is assumed to be nontoxic, and it is membrane impermeable and highly dissociated at physiological pH values.
Endoxifen Z-isomer hydrochloride is a Tamoxifen metabolite and a potent estrogen receptor (ER) antagonist that concentration-dependently inhibits hERG with an IC50 value of 1.6 μM.
YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity. YUM70 induces endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer.
Phellodendrine chloride is an alkaloid in Phellodendron amurense. Phellodendrine chloride inhibited the proliferation of KRAS mutant pancreatic cancer cells by inhibiting the absorption of macropinocytosis.
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza glabra, which inhibits aldose reductase with an IC50 of 320 nM.
Naloxone hydrochloride is an opioid inverse agonist compound used to counter the effects of opiate overdose.
AMG-510 racemate is a racemic of AMG-510, which is a potent KRAS G12C covalent inhibitor.