Icariin is a flavonol glycoside. Icariin inhibited PDE5 and PDE4 activity with IC50 of 432 nM and 73.50 μM, respectively. Icariin is also a PPARα activator. Icariin can increase cardiovascular and cerebrovascular blood flow, promote hematopoiesis, immunity and bone metabolism.
Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2.
Stavudine (D4T) is a potent inhibitor of HIV-1 reverse transcriptase in vitro. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis.
Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM.
Hederacoside C (HDC) is one of the active ingredients in Hedera helix leaf extract (Ivy Ex.)
Norepinephrine is generally considered to be a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.
Dexmedetomidine is a potent and highly selective α-2 adrenergic receptor agonist with sedative effects.
Luminespib (AUY922) is a small molecule Heat Shock Protein 90 (HSP90) inhibitor with IC50 values of 13 and 21 nM for HSP90α and HSP90β respectively.
PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that restores mitochondrial cytochrome c oxidase subunit 1 levels, rescues impairments of mitochondrial motility and neurite outgrowth.
Coptisine chloride is an effective and non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM. Coptisine chloride is an effective H1N1 neuraminidase (NA-1) inhibitor with IC50 of 104.6 μg/mL, which can be used for influenza A virus (H1N1) infection.
LY333531 hydrochloride competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively).
Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM.