Quercitrin (Quercitrin) is a natural compound in bitter buckwheat, which has anti-inflammatory effects and has the potential to be used in cardiovascular disease research.
Curdione, a sesquiterpenoid isolated from Zedoary, has high biological activity and has the effects of inhibiting platelet aggregation and preventing thrombosis.
Piperlongumine, a natural alkaloid from Piper longum L., is also a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1.
α-Lactose is the major sugar present in milk. Lactose exists in the form of two anomers, α and β. Lactose is a very important sugar because of its abundance in the milk of humans and domestic animals.
Protoescigenin is the main glycoside of the horse chestnut saponin mixture. Protoescigenin can be used as a substrate for exploratory chemical reactions for selective protection, followed by the formation of propyl ethers, which are subsequently condensed with azido-monosaccharides to obtain new triterpenetriazole-linked conjugates.
DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.
Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively.
HS38 is a potent, selective, ATP-competitive inhibitor of DAPK1 and ZIPK (DAPK3) with Kd values of 300 nM and 280 nM, respectively.In addition, HS38 is an inhibitor of PIM3 with an IC50 value of 200 nM.HS38 has been used in the study of smooth muscle-related diseases.
Formoterol Hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease.
Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, orally active inhibitor of cholesterol 24-hydroxylase (CH24H), which is used in the study of epilepsy syndromes.
JC124 IS A SPECIFIC INHIBITOR OF THE NLRP3 INFLAMMASOME. JC124 HAS ANTI-INFLAMMATORY AND NEUROPROTECTIVE EFFECTS.