CYN 154806, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist.
Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM).
Brigimadlin (BI 907828) is an E3 ubiquitin-protein ligase MDM-2 inhibitor. Brigimadlin serves as an antineoplastic agent.
Tegoprazan (CJ-12420, IN-A001, K-CAB, LXI-15028) is a potassium-competitive acid blocker and a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro.
CHAPS is a non-denaturing, zwitterionic detergent that dissolves membrane proteins. CHAPS are used to stabilize various protein-DNA complexes and can preserve the biochemical activity of proteins in solution.
GLP-26 is an HBV capsid assembly modulators (CAM), inhibits HBV DNA replication (IC50=3 nM) in Hep AD38 system, and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools.
Bendazac is an oxyacetic acid with anti-inflammatory, antinecrotic, choleretic and antilipidaemic properties. Bendazac acts by preventing protein denaturation.
LYS-006 hydrochloride is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) with IC50 of 2 nM. LYS-006 hydrochloride can be used for the research of inflammatory and autoimmune disorders, including ulcerative colitis and NASH.
Daprodustat (GSK1278863) is a novel, first-in-class, orally active inhibitor of hypoxia-induced factor prolyl hydroxylase (HIF-PHI). Reversible inhibition of HIF-PHD activity under normal partial oxygen pressure can temporarily inhibit HIF-α degradation and promote the expression of related hypoxia metabolism genes.
QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells.