Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure.
Ginsenoside Rg5 is the main ingredient of red ginseng. Ginsenoside Rg5 blocks the binding of IGF-1 to its receptor with an IC50 of about 90 nM. Ginsenoside Rg5 also inhibited COX-2 mRNA expression by inhibiting DNA binding activity of NF-κB P65.
Lorcaserin hydrochloride is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM.
3-Methylcholanthrene, a dioxin-like compound and also an inducer of cytochrome P4501A, can be used to construct animal models of leukemia. 3-Methylcholanthrene is a carcinogen used to induce transformation of cultured cells. It is also used to induce fibrosarcomas and skin carcinomas in laboratory animals. 3-methylcholanthrene is a potent aryl hydrocarbon...
CY-09 is a selective direct inhibitor of NLRP3 with anti-inflammatory and antidepressant activity, which inhibits inflammatory cytokine production and TRPA1 activation by inhibiting the activation of the NLRP3 inflammatory vesicle, thereby decreasing the intracellular Ca2+ level and reducing the pro-inflammatory polarization of macrophages, alleviating...
CP-424174 is a cytokine release inhibitory compound (CRID) and also a reversible IL-1β inhibitor with an IC50 of 210 nM, which inhibits post-translational processing and secretion of IL-1β in human monocytes in the presence of LPS and ATP.
NBQX (FG9202) is a potent and selective AMPA receptor antagonist. NBQX has neuroprotective and anticonvulsant activity. It is more selective than CNQX.
MBX-2982 is a selective, orally-available GPR119 agonist for the treatment of type 2 diabetes.
Tivantinib (ARQ 197) is a selective and oral small-molecule inhibitor of c-Met with a minimal IC50 value of 0.1 μM.
Balsalazide is an anti-inflammatory compound used to study inflammatory bowel disease and ulcerative colitis.