A-196 is a potent selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM, respectively, and biochemically inhibits SUV4-20 in a substrate-competitive manner. In addition, A-196 is a first-in-class chemical probe for SUV4-20, which can be used to study the role of histone methyltransferases in genome integrity.
TTNPB (Arotinoid Acid) is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively.
Tc-e 5003 is a selective inhibitor of PRMT1 with an IC50 of 1.5 µM against hPRMT1. Tc-e 5003 has anti-inflammatory properties in TLR4 signal transduction.
Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent.
Clovamide is a natural phenolic compound with anti-inflammatory and neuroprotective effects, a potent antioxidant, and an excellent ROS and oxygen free radical scavenger.
Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines.
SB-207266 is a potent, selective, orally active and long-acting 5-HT4 antagonist in vivo.
OAC1 (Oct4-activating compound 1) is a potent Oct4 activator that activates both the Oct4 and Nanog promoters, promotes induced multifunctional stem cell (iPSC) formation, and activates OCT4 through upregulation of HOXB4 expression.Additionally, OAC1 increases the transcription of the Oct4-Nanog-Sox2 triplet and TET1 and promotes cell reprogramming by...
Nvp-tae 226 (TAE226) is a potent atP-competitive dual FAK and IGF-1R inhibitor with IC50 of 5.5 nM and 140 nM, respectively. Nvp-tae 226 (TAE226) also effectively inhibited Pyk2, insulin receptor (InsR), with IC50 of 3.5 nM and 40 nM.
4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker.