Gefitinib Hcl(ZD-1839 Hcl) is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells. Therefore, it is only effective in cancers with mutated and overactive EGFR.
BMOV is a potent oral vanadium complex with anti-diabetic properties andinsulin-mimicking effects.BMOV is shown to improve cardiac dysfunctions in diabetic models.
PR-619 is a broad-spectrum reversible DUB (deubiquitinating enzyme) inhibitor of USP2, USP4, USP5, USP7 and USP8 with an EC50 of 3-9 μM. PR-619 also induces endoplasmic reticulum stress and endoplasmic reticulum stress-associated apoptosis.
MSC2530818, a CDK8 inhibitor with the IC50 of 2.6 nM, displays excellent kinase selectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable.
MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG) and a telomerase inhibitor. It can be used in the study of tumors such as multiple myeloma (MM).
Terlipressin diacetate is a vasopressin analogue and a highly selective vasopressin V1 receptor agonist that reduces visceral blood flow and portal vein pressure and controls acute varicose rupture bleeding. Terlipressin diacetate has anti-inflammatory and antioxidant effects and can be used to study hepatorenal syndrome and norepinephrine-resistant...
RBPJ Inhibitor-1 (RIN1) is a first-in-class RBPJ inhibitor that blocks the interaction between RBPJ and SHARP.RBPJ Inhibitor-1 (RIN1) inhibits the proliferation of Notch-dependent tumor cells.
Cyanine5.5 amine is a Cy5.5 analog that is also a near-infrared (NIR) fluorescent dye (Ex=648 nm, Em=710 nm) and has the advantage of a low fluorescent background. It can be used to prepare Cy5.5-labeled nanoparticles for tracking and imaging using confocal microscopy.
Hemicholinium 3 is a compound which blocks the reuptake of choline by the high-affinity choline transporter (ChT) at the presynapse. Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a Ki value of 25 nM.
COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity.