Chemical
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Chemical Hay 28543 productos.
PP2 (AGL 1879)
PP2 is a selective inhibitor of Src-family tyrosine kinases with >10,000-fold selectivity over ZAP-70 and JAK2.
GDC-0276
GDC-0276 is a potent, selective, reversible and orally active NaV1.7 inhibitor with an IC50 value of 0.4 nM. GDC-0276 is well tolerated and exhibits a good pharmacokinetic profile. GDC-0276 has the potential for the treatment of pain and to address shortcomings of existing pain medications, such as addiction and off-target side effects.
RIPA-56
RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM.
Lysophosphatidylcholines
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL).
Valacyclovir hydrochloride
Valaciclovir HCl, an aciclovir procompound, inhibits activity of virus DNA polymerase, used to treat infections caused by herpes simplex virus (HSV) and varicella zoster virus, and for prophylaxis against cytomegalovirus (CMV).
Tyrphostin AG528
Tyrphostin AG528 (Tyrphostin B66) is an inhibitor of EGFR and ErbB2 with IC50 values of 4.9 and 2.1 μM, respectively.
Sematilide hydrochloride
Sematilide (CK-1752) hydrochloride is a novel class III antiarrhythmic agent.
Clonidine hydrochloride
Clonidine hydrochloride is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.
GSK805
GSK805 is a potent, orally bioavailable RORγγ Inhibitor, with pIC50 of 8.4 and >8.2 for RORγ FRET assay and Th17 assay.
Nisoxetine hydrochloride
Nisoxetine hydrochloride is a potent, selective norepinephrine transporter inhibitor (Ki = 5.1 nM).
Bullatine-B
Neoline (Bullatine B), the active ingredient of Aconitum root (PA), mitigated oxaliplatin induced peripheral neuropathy in mice. Neoline can be used as a marker compound to determine the quality of PA products used to study neuropathic pain.
Verteporfin (CL 318952)
Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin (CL 318952) is a YAP inhibitor that disrupts YAP-TEAD interactions, and it is also an inhibitor of autophagy.