Dupilumab (dupilumab) is a potentially first-in-class, fully human monoclonal antibody against IL-4 receptor alpha (IL-4Rα) that inhibits IL-4 and IL-13 signaling and can be used in studies related to atopic dermatitis and asthma.
Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP is a secreted contains one C-type lectin domain, high expressed in the gastrointestinal tract, including jejunum, ileum, appendix, pancreas and small intestine. In the acid environment, REG4 can maintain carbohydrate recognition activity. REG4 may be involved in...
Recombinant Human RANK (C-6His) is produced by Mammalian expression system and the target gene encoding Ile30-Pro212 is expressed with a 6His tag at the C-terminus.
Recombinant Human BMP-2 was prepared by escherichia coli expression system. Human Bone Morphogenetic Protein-2 (BMP-2) is a bone-growth regulatory factor and belongs to the transforming growth factor-beta (TGF-beta) superfamily. Measured by its ability to induce alkaline phosphatase production by C2C12 cells, the ED50 is typically 0.2-1 µg/ml.
R-spondin-3 (RSPO3) is a member of the thrombospondin type 1 repeat supergene family. RSPO3 founctions as a activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation.
Recombinant human Neuregulin-1 Beta is produced by the escherichia coli expression system and the target gene encoding Ser2-Lys246 is expressed. Accession # : AAA58639.1.
The stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF-1 binds primarily to CXC receptor 4 (CXCR4; CD184). The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals...
Macrophage inflammatory protein 1β (MIP-1β), also known as Chemokine (C-motif) ligand 4 (CCL4), is a small cytokine in the CC Chemokine family. It is a chemical attractant for natural killer cells, monocytes and a variety of other immune cells. Protein structure: MIP-1β (ALA24-ASN92), Accession # P13236-1.
Recombinant Rat EGF Protein is type Itransmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc.
Recombinant Mouse IGF-I belongs to the IGF family of peptides, which also includes IGF-II and insulin. IGF-I executes its functions via signaling through transmembrane tyrosine receptors (IGF Receptors). ED50 < 10.0 ng/ml, measured by a cell proliferation assay using FDC-P1 cells, corresponding to a specific activity of > 1.0 × 105 units/mg.
Ciliary Neurotrophic Factor (CNTF) is a kind of polypeptide hormone that acts on nervous system, promoting neurotransmitter synthesis and neurite growth in some neuron populations.
Biological activity: PD-1 is mainly expressed in activated T cells and B cells, and its function is to inhibit cell activation, which is a normal self-stabilizing mechanism of the immune system. Because excessive T/B cell activation can cause autoimmune diseases, PD-1 is a talisman of our body.