Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells.
EGFR, also known as ERBB, ERBB1 and HER1, is a type I transmembrane protein belonging to the tyrosine protein kinase family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. EGFR also directly...
Recombinant Human CD14 is produced by Mammalian expression system and the target gene encoding Thr20-Cys352 is expressed with a 6His tag at the C-terminus. CD14 is a cell surface glycoprotein that is preferentially expressed on monocytes/macrophages. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a pattern...
The recombinant human IL1F9 consists of 168 amino acids and predicts a molecular mass of 19.1 KDa. A DNA sequence encoding the mature form of human IL1F9 (Ser18-Asp169) was expressed with a polyhistide tag at the N-terminus.
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 plays an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells and...
Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the interleukin 6 (IL-6) family, which also includes IL-6, tumor suppressor M, leukemia suppressor (LIF) and cardiac trophic factor-1. In structure, CNTF is similar to the composition of a quadruhelical bundle, similar to other members of the IL-6 family. Protein structure: CNTF (ALA2-MET200),...
It induces various cytokines such as TNFA/TNF-α and IL8. it activates the typical cytokine signaling pathways NF-kappa-B and p38 MAPK. accession # P24001.
Sonepcizumab (LT 1009) is a fully humanized anti-S1P monoclonal antibody. Sonepcizumab has the potential for the research of metastatic renal cell carcinoma (mRCC).
Recombinant Human Vimentin Protein is a type III intermediate filament protein, which mainly exists in cells of mesenchymal origin, such as vascular endothelial cells and blood cells, and is the main component of the cytoskeleton.
Recombinant Human GPNMB (Glycoprotein Non-Metastatic Melanoma Protein B) is produced by Mammalian expression system and the target gene encoding Ala22-Pro486 is expressed with a 6His tag at the C-terminus. Osteoactivin is an intracellular glycoprotein belongs to the NMB/pMEL-17 family, which is asscociated with cell endosomal/lysomal compartments.
T-cell Immunoglobulin and Mucin Domain-containing Protein 4(TIM-4) belongs to the immunoglobulin superfamily. TIM-4 is expressed by macrophages and mature dendritic cells but not by lymphocytes. it is Involved in regulating T-cell proliferation and lymphotoxin signaling.
Hepatocyte growth factor, also known as HGF, belongs to the peptidase S1 family, plasminogen subfamily. The hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor, and acts as a multi-functional cytokine on cells of mainly...