Chemical
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- Catálogos PDF
Chemical Hay 28543 productos.
MGCD265
MGCD265 is a novel multitargeted receptor tyrosine kinase (RTK) inhibitor that targets the mesenchymal epithelial transition (c-Met) and the vascular endothelial growth factor (VEGF) receptors (VEGFR1, VEGFR2, and VEGFR3).
CDDO-Im
CDDO Im (RTA-403) is the activator of Nrf2 and PPAR with Ki of 232 nM and 344 nM for PPARα and PPARγ, respectively.
ML364
ML364 is a small molecule inhibitor of the deubiquitinase USP2 (IC50=1.1 μM, Kd=5.2 μM) with potential anticancer activity. ML364 induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP.
AZD5582
AZD5582 is an IAP antagonist that can be effectively combined with bir3 domains of cIAP1, cIAP2, and XIAP, IC50 The values are 15, 21, 15 nM, respectively. AZD5582 Induces apoptosis.
Coumarin 6
Coumarin 6 is a fluorescent dye frequently used to facilitate the traceability of drug delivery systems in vitro.
10-Deacetyl-7-xylosyl paclitaxel
10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility.
Setmelanotide
Setmelanotide is a selective agonist of the MC4 receptor, with EC50 values of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.
Zatebradine
Zatebradine(UL-FS49) is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner; 92% inhibition of the hHCN1-mediated current at 10 uM.
6-Methoxyflavanone
6-Methoxyflavanone is an inhibitors of bitter taste receptor.
Cidofovir
Cidofovir (Vistide) is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis.
Schizandrin-A
Schizandrin-A, a lignan from Schisandra chinensis, is also a novel heat shock factor 1 (HSF1) inhibitor that effectively inhibits the induction of HSF1 target proteins such as heat shock protein 70 (HSP70) and HSP27. In addition, Schizandrin-A also regulates lipid metabolism and oxidative stress and possesses neuroprotective activity.
Quetiapine
Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor.