Chemical
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- Catálogos PDF
Chemical Hay 28543 productos.
CY-09
CY-09 is a selective direct inhibitor of NLRP3 with anti-inflammatory and antidepressant activity, which inhibits inflammatory cytokine production and TRPA1 activation by inhibiting the activation of the NLRP3 inflammatory vesicle, thereby decreasing the intracellular Ca2+ level and reducing the pro-inflammatory polarization of macrophages, alleviating...
AVN-492
AVN-492 is a potent and selective 5-HT6R antagonist, binds to 5-HT6R (Ki = 91 pM).
LDN-212854
LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.
SBC-110736
SBC-110736 is a novel inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9).
Vorinostat
Vorinostat (SAHA, Zolinza, MK-0683) is a selective and potent histone deacetylase (HDAC) inhibitor with the IC50 value of 10 nM for HDAC-1.
Acebilustat
Acebilustat is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory drug.
Epoxomicin
Epoxomicin (BU-4061T) is a cell-permeable, selective and irreversible proteasome inhibitor with an IC50 value of 4 nM. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier.
Fisetin
Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.
PRT-060318
PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, with IC50 of 4 nM.
Timosaponin-A3
Timosaponin AIII could inhibit the activity of acetylcholinesterase (AChE) with IC50 value of 35.4 μM.
Ulixacaltamide
Ulixacaltamide (Z944) is an orally active T-type calcium channel antagonist that rescues impairments in crossmodal and visual recognition memory.
KH-3
KH-3 is a potent RNA-binding protein Hu antigen R (HuR) inhibitor with an IC50 value of 0.35 μM. KH-3 has anti-proliferative activity. KH-3 suppresses breast cancer cell invasion as well as delays the initiation of lung colonies by disrupting HuR-FOXQ1 mRNA interaction.