Chemical
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- Catálogos PDF
Chemical Hay 28543 productos.
NLRP3/AIM2-IN-3
NLRP3/AIM2-IN-3 is a potent inhibitor that interferes with the interaction of NLRP3 or AIM2 with the bridging protein ASC and inhibits ASC oligomerization, and has different species-specific effects on NLRP3 and AIM2 inflammasome-dependent pyroptosis. In addition, NLRP3/AIM2-IN-3 inhibited LPS/nigericin-stimulated cell pyroptosis in THP-1 macrophages with...
C188-9
C188-9 is a small-molecule STAT3 inhibitor, can block Th2 and Th17 cell expansion and cytokine production to prevent house dust mite (HDM)-induced airway inflammation and remodeling.
Meclocycline Sulfosalicylate
Meclocycline is a tetracycline antibiotic. Meclocycline sulfosalicylate prevents bacterial protein synthesis through 30S ribosome-mediated chain elongation and blocks amino-acyl tRNA A-site binding.
Cytisine
Cytisinicline (Cytisine) is an alkaloid that can be extracted from Laburnum and Cytisus. Cytisinicline (Cytisine) is a partial agonist of α4β2 nicotinic acetylcholinergic receptors (α4β2 nAChRs), and also a partial agonist of α4β2 and α7 receptors. It has been used medically to help people quit smoking.
Tidiacic
Tidiacic acid, a carboxylic acid derivative, can be used as pharmaceutical intermediates.
Acalisib
Acalisib (GS-9820) is a potent and selective PI3Kδ inhibitor with an IC50 of 12.7 nM, with potential immunomodulating and antineoplastic activities.
Substance P TFA
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
Istradefylline
Istradefylline (KW-6002) is a potent, selective and orally active adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM.
Lacto-N-fucopentaose III
Lacto-N-fucopentaose III (LNFP-III) is an immune modulator.
INDORAMIN HYDROCHLORIDE
Indoramin is a selective alpha 1-antagonist which reduces blood pressure without reflex tachycardia and can cause a bradycardia.
Gambogic amide
Gambogic amide is a potent and selective agonist of TrkA and also induces its tyrosine phosphorylation and activation of downstream signaling, including Akt and MAPK.
KRN 633
KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM, weakly inhibits PDGFR-α/β and c-Kit, does not block the phosphorylation of FGFR-1, EGFR or c-Met in cell.