Curcumin analogue C1 is an effective oral activator of transcription factor EB (TFEB), which can be used in the study of neurodegenerative diseases.
Atamparib (RBN-2397) is a potent, orally active NAD+ competitive PARP7 inhibitor with an IC50 value of less than 3 nM. Atamparib (RBN-2397) can directly inhibit cell proliferation and restore type I interferon signaling by inhibiting PARP7 in tumor cells to stimulate innate or adaptive antitumor immune responses.
Atamparib (RBN-2397) is a potent, orally active NAD+ competitive PARP7 inhibitor with an IC50 value of less than 3 nM. Atamparib (RBN-2397) can directly inhibit cell proliferation and restore type I interferon signaling by inhibiting PARP7 in tumor cells to stimulate innate or adaptive antitumor immune responses.
Jbsnf-000088 (6-methoxynicotinamide) is a niacinamide (NA) analogue, which is a potent NNMT inhibitor. Jbsnf-000088 (6-methoxynicotinamide) is a niacinamide n-methyl transferase (NNMT) inhibitor. The IC50 of monkey NNMT and mouse NNMT were 1.8 µM, 2.8 µM and 5.0 µM, respectively. In animal models of metabolic diseases, JBSNF-000088 inhibits NNMT activity,...
3-Bromopyruvate (3-Bromopyruvic acid) is a hexokinase II inhibitor, which is an effective antitumor agent on the hepatoma cells.
CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8) with Kd of 220 nM and IC50 of 67 nM in assay.
DIDS sodium salt (MDL101114ZA) is a dual ABCA1 and VDAC1 inhibitor. DIDS sodium salt is also an anion transport inhibitor, which inhibits the ClC-Ka chloride channel and the bacterial ClC-ec1Cl-/H+ exchanger with IC50s of 100 μM and ~300 μM, respectively.
NGI-1 (ML414) is an inhibitor of Asparagine (N)-linked glycoslysation, which inhibits the oligosaccharyltransferase, preventing the attachment to the protein.