STX-478 is a mutation-selective variant PI3Ka inhibitor for studies related to breast cancer and other solid tumors.
NX-2127 is an orally active, potent BTK inhibitor that induces degradation of mutant BTKC481S in cells, as well as inhibits the proliferation of BTKC481S mutant TMD8 cells. In addition, NX-2127 stimulates T cell activation and increases IL-2 production in primary human T cells.
Abiraterone decanoate is a novel, long-acting Abiraterone precursor compound that also exhibits high CYP17 cleavage enzyme inhibition selectivity for prostate cancer related studies.
Abiraterone decanoate is a novel, long-acting Abiraterone precursor compound that also exhibits high CYP17 cleavage enzyme inhibition selectivity for prostate cancer related studies.
VBIT-4 is a voltage-dependent anion channel (VDAC1) oligomer inhibitor with a Kd value of 17 μM.In addition, VBIT-4 is an inhibitor of apoptosis and can be used in studies related to neurodegenerative and cardiovascular diseases.
STL1267 is a potent REV-ERB agonist that crosses the blood-brain barrier with a Ki value of 0.16 µM for REV-ERBα. STL1267 showed no cytotoxicity and inhibited BMAL1 gene expression.
CPM is a maleimide derivative that can be used as a blue fluorescent thiol reactive dye with excitation and emission maxima at 384 nm and 470 nm.
H-D-Phe-Pip-Arg-pNA (S-2238) hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin.