Valbenazine (NBI-98854) is a vesicular monoamine transporter-2 (VMAT2) inhibitor with a Ki of 110-190 nM.
Rhodamine 123 is a membrane-permeable cationic green fluorescent dye that can be easily absorbed by active mitochondria without cytotoxicity. The maximum excitation/emission wavelength is 508nm/530nm, giving green fluorescence for observation of mitochondria, stored in refrigerators (-5 to -30°C) and protected from light.
Rhodamine 123 is a membrane-permeable cationic green fluorescent dye that can be easily absorbed by active mitochondria without cytotoxicity. The maximum excitation/emission wavelength is 508nm/530nm, giving green fluorescence for observation of mitochondria, stored in refrigerators (-5 to -30°C) and protected from light.
RBN012759 is a potent, selective and orally active PARP14 inhibitor with IC50 values of
AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM.
AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM.
Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP.
MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent.
N6,N6-Dimethyladenosine is a modified ribonucleoside previously found in rRNA, and also exhibits in mycobacterium bovis Bacille Calmette-Guérin tRNA.
Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP.