YAP/TAZ inhibitor-2 is a potent, orally bioavailable TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM that exhibits anticancer and antiproliferative activity.
Syringaresinol has anti-inflammatory activity. Syringaresinol also causes vasorelaxation. Syringaresinol elevates NO production through the phosphorylation and dimerization of endothelial NO synthase.
Syringaresinol has anti-inflammatory activity. Syringaresinol also causes vasorelaxation. Syringaresinol elevates NO production through the phosphorylation and dimerization of endothelial NO synthase.
3-Epiwilsonine is an alkaloid from Cephalotaxus wilsoniana, exhibits effect on acute and chronic myeloid leukemia and malignant lymphoma.
Syringaresinol has anti-inflammatory activity. Syringaresinol also causes vasorelaxation. Syringaresinol elevates NO production through the phosphorylation and dimerization of endothelial NO synthase.
Pavinetant is a neurokinin-3 receptor (NK3R) antagonist that may be used in studies related to hot flashes and polycystic ovary syndrome.
Pavinetant is a neurokinin-3 receptor (NK3R) antagonist that may be used in studies related to hot flashes and polycystic ovary syndrome.
Londamocitinib is a potent and selective JAK1 inhibitor with anti-inflammatory activity.
Zidesamtinib is a potent, selective, orally active and blood-brain barrier permeable inhibitor of multiple ROS1 fusion and resistance mutations, with IC50 values of 0.7 and 7.9 nM for wild-type ROS1 and ROS1 G2032R, respectively, and does not inhibit TRK.May be useful in studies related to non-small cell lung cancer and other solid tumors.
NT-0796 is an isopropyl ester that is converted intracellularly to NDT-197959 and is also a selective, CNS-transmitting NLRP3 inhibitor with an IC50 of 0.32 nM in PBMC.May be used in studies related to neuroinflammatory diseases.