Cefazolin is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis.
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.
Danthron functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a synthetic anthraquinone derivative, currently used as an antioxidant in synthetic lubricants, in the synthesis of antitumor agents, as a fungicide and as an intermediate for making dyes.
Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM.
Elamipretide TFA, also known as MTP-131, is a cardiolipin peroxidase inhibitor and mitochondria-targeted peptide.
GSK 4112 is a selective Rev-Erbα agonist with an EC50 value of 0.4 μM, which can be used to explore the function of Rev-erbα in transcriptional repression, biological regulation of circadian rhythms and metabolic pathways.
Licarin B, derived from the seed of Myristica Fragrans, is an inhibitor of NO production that improves insulin sensitivity by activating PPARγ and GLUT4 in the IRS-1/PI3K/AKT pathway.
Meclocycline is a tetracycline antibiotic. Meclocycline sulfosalicylate prevents bacterial protein synthesis through 30S ribosome-mediated chain elongation and blocks amino-acyl tRNA A-site binding.
Isopsoralenoside is a benzofuran glycoside from Psoralea corylifolia. Isopsoralenoside show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.