Lupenone plays a role through the PI3K/Akt/mTOR and NF-κB signaling pathways. Lupenone has anti-inflammatory, antiviral, antidiabetic and anticancer activities.
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.
β-Melanocyte Stimulating Hormone TFA, human is a 22-residue peptide, which acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.
Omiganan is a novel synthetic cationic antimicrobial peptide containing 12 amino acids, as well as a synthetic analog of indolemycin, with broad-spectrum antimicrobial and antibiofilm activity. It can be used in studies related to atopic rhinitis.
CHAPS is a non-denaturing, zwitterionic detergent that dissolves membrane proteins. CHAPS are used to stabilize various protein-DNA complexes and can preserve the biochemical activity of proteins in solution.
L-Methionine sulfoxide (H-Met(O)-OH), a metabolite of methionine, induces polarization of M1/classical macrophages and regulates signaling parameters for oxidative stress and purine energy.
Larazotide acetate also known as AT-1001, is a tight junction regulator and reverses leaky junctions to their normally closed state. Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively.
Dehydroandrographolide succinate, extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has immunostimulatory, anti-infective and anti-inflammatory effect.
Simlukafusp alfa (FAP-IL2v) is an immunocytokine comprising an antibody against fibroblast activation protein α (FAPα) and an IL-2 variant that only binds IL-2Rβγ. Isotype: human IgG1.
QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells.
Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).