Latrunculin A (Latrunculia magnifica) is A toxin obtained from the Red Sea sponge Latrunculia magnifica that binds to actin monocytes and inhibits actin aggregation, inhibiting atP-actin, ADP-pi-actin, Kd values of ADP-actin and G-actin were 0.1, 0.4, 4.7 μM and 0.19 μM, respectively.
Butoconazole (RS-35887) is an antifungal agent that inhibits phA-stimulated secretion of cytokines such as IL-2, TNFα, IFN and GM-CSF in human peripheral blood lymphocytes. IC50 were 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively.
Velpatasvir is a second-generation NS5A inhibitor that inhibits hepatitis C viral replication through acting on the crucial "membranous web" that facilitates RNA replication.
BMS-193885 is a potent, selective Y1 antagonist that is active in both acute and chronic animal models of food intake.
Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) has the antiplatelet effect of Ca2+ antagonist with IC50 of 155 μM. Ginsenoside Ro decreased TXA2 production and Ginsenoside Ro also slightly decreased COX-1 and TXAS activity.
COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity.
Apraclonidine hydrochloride is a selective α2 and weak α1 receptor agonist that reduces intraocular fluid production and increases drainage, and may be used in studies related to glaucoma.
Ailanthone is a potent inhibitor of both full-length androgen receptor (AR) (IC50=69 nM) and constitutively active truncated AR splice variants (AR1-651 IC50=309 nM).
Thymosin alpha 1 (Thymalfasin) is an immunomodulating agent able to enhance the Thl immune response.
CHIR-98014 is a potent and selective GSK-3 inhibitor for GSK-3ɑ and GSK-3β with IC50 of 0.65 nM and 0.58 nM, respectively.