Sennidin B can be isolated from Cassia Angustifolia and is an isomer of Sennidin A with lower activity than Sennidin A. Sennidin A inhibited HCV NS3 helicase with an IC50 value of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4). Sennidin A stimulates glucose incorporation.
Sb-505124 is a selective inhibitor of TGF-βI receptor (ALK4, ALK5, ALK7) with IC50 values of 129 nM and 47 nM for ALK4 and ALK5, respectively. Sb-505124 also inhibits ALK7, but not ALK1, 2, 3 and 6.
Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 µM, respectively.
Xanthosine 5' -Monophosphate sodium Salt is an intermediate of purine metabolism and a product of rate-limiting step in guanosine production, which is of great significance in the synthesis of DNA, RNA and glycoproteins.
Momordin-Ic is a SENP1 Inhibitor. Momordin Ic induces apoptosis through oxidative stress-regulated mitochondrial dysfunction.
EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively.
RAS-IN-2 (RMC-6236) is a potent pan-KRAS inhibitor targeting activation-state KRAS for cancer-related studies.
Cantharidin is a natural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively). Displays > 500-fold selectivity over PP2B.