IMT1

IMT1 is the first, specific and non-competitive inhibitor of human mitochondrial RNA polymerase (POLRMT). IMT1 induces conformational changes in POLRMT that block substrate binding and transcription in a dose-dependent manner in vitro. IMT1 reduced deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in significant depletion of cellular amino acid levels.