VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50 = 3 μM).
VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively.
VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively.
VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively.
VT-1598 is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 shows anti-fungal activity against Candida auris.
VT-1598 is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 shows anti-fungal activity against Candida auris.
VT-1598 is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 shows anti-fungal activity against Candida auris.
VT-1598 is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 shows anti-fungal activity against Candida auris.
VT103, a VT101 analog, is a selective and orally active TEAD1 protein palmitoylation inhibitor that can be used in cancer research. VT103 inhibits the transcription of YAP/TAZ-TEAD promoted gene, blocks the auto-palmitoylation of TEAD, and interferes with the interaction between YAP/TAZ and TEAD.
VT103, a VT101 analog, is a selective and orally active TEAD1 protein palmitoylation inhibitor that can be used in cancer research. VT103 inhibits the transcription of YAP/TAZ-TEAD promoted gene, blocks the auto-palmitoylation of TEAD, and interferes with the interaction between YAP/TAZ and TEAD.
VT103, a VT101 analog, is a selective and orally active TEAD1 protein palmitoylation inhibitor that can be used in cancer research. VT103 inhibits the transcription of YAP/TAZ-TEAD promoted gene, blocks the auto-palmitoylation of TEAD, and interferes with the interaction between YAP/TAZ and TEAD.
The pan-TEAD transcription factor inhibitor VT-104 binds to a lipid pocket on TEAD, preventing its auto-palmitoylation, similar to the previously highlighted TEAD inhibitors.