AICAR is an adenosine analog and activator of AMPK that regulates glucose and lipid metabolism and inhibits the production of pro-inflammatory cytokines and iNOS. In addition, AICAR is an inhibitor of autophagy, YAP and mitophagy.
Ailanthone is a potent inhibitor of both full-length androgen receptor (AR) (IC50=69 nM) and constitutively active truncated AR splice variants (AR1-651 IC50=309 nM).
Ailanthone is a potent inhibitor of both full-length androgen receptor (AR) (IC50=69 nM) and constitutively active truncated AR splice variants (AR1-651 IC50=309 nM).
Ajmalicine (Raubasine) is an adrenolytic agent which preferentially blocks alpha 1-adrenoceptor than alpha 2-adrenoceptor. Ajmalicine (Raubasine) is an reversible non-competitive nicotine receptor antagonist with an IC50 of 72.3 μM.
AK-1 is a cell permeable, potent and specific SIRT2 inhibitor with an IC50 of 12.5 μM, it induced proteasomal degradation of the Snail transcription factor.
AK-1 is a cell permeable, potent and specific SIRT2 inhibitor with an IC50 of 12.5 μM, it induced proteasomal degradation of the Snail transcription factor.
AK-1 is a cell permeable, potent and specific SIRT2 inhibitor with an IC50 of 12.5 μM, it induced proteasomal degradation of the Snail transcription factor.