AGI-5198 (IDH-C35) is the first highly potent and selective inhibitor of IDH1 R132H and R132C mutants in vitro with IC50 values of 0.07 μM and 0.16 μM, respectively.
Agmatine sulfate is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis.
Agmatine sulfate is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis.