Catalpol (Catalpinoside), is a kind of irisin found in Rehmannia glutinosa, with neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-convulsive, antioxidant and anti-HBV effects.
Doramectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. It is used for the treatment and control of internal parasitosis, ticks and mange.
BLU9931 is a potent, selective, and irreversible FGFR4 inhibitor with IC50 of 3 nM, about 297-, 184-, and 50-fold selectivity over FGFR1/2/3, respectively.
Ferulic Acid is a hydroxycinnamic acid and a type of organic compound found in the Ferula assafoetida L. or Ligusticum chuanxiong.
ar-Turmerone is a major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone activates apoptotic protein in human lymphoma U937 cells.
Pyrene is a polycyclic aromatic hydrocarbon (PAH) consisting of four thickened benzene rings that exhibits strong fluorescence, emitting in the blue region of the spectrum, and can be used as a probe of molecular interactions in solution and on surfaces, as well as in studies related to PAHs in the environment and biological systems.
Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.
Elenbecestat (E2609) is a highly potent, orally active BACE-1 inhibitor that transmits CNS. Elenbecestat has the potential to be used in the study of Alzheimer's disease (AD).
Rrx-001 is a hypoxic selective epigenetic factor that has been used as a radiation or chemotherapy sensitizer to induce apoptosis. Rrx-001 is an immune checkpoint inhibitor that down-regulates CD47 and SIRP-α. Rrx-001 is also an effective inhibitor of G6PD with strong antimalarial activity. Rrx-001 inhibits the expression of CD47 in tumor cells by...