SAR407899 is a potent and selective, ATP-competitive ROCK inhibitor with IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.
Tetramethylrhodamine ethyl ester (TMRE) can bind to mitochondria and produce orange fluorescence with a maximum excitation/emission wavelength of 550nm/576nm, which is often used to observe mitochondria. Store in refrigerator (-5 to -30°C) away from light.
Tetramethylrhodamine ethyl ester (TMRE) can bind to mitochondria and produce orange fluorescence with a maximum excitation/emission wavelength of 550nm/576nm, which is often used to observe mitochondria. Store in refrigerator (-5 to -30°C) away from light.
2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. 2-D08 also inhibits Axl with an IC50 of 0.49 nM.
2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. 2-D08 also inhibits Axl with an IC50 of 0.49 nM.
Lixumistat (IM156) is a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial metabolic reprogramming and inhibit lung fibrosis. Lixumistat (IM156) is a metformin derivative, which increases AMPK phosphorylation.
Lixumistat (IM156) is a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial metabolic reprogramming and inhibit lung fibrosis. Lixumistat (IM156) is a metformin derivative, which increases AMPK phosphorylation.
MPP+ iodide is a toxic metabolite of the neurotoxin MPTP, MPP+ iodide causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra.
MPP+ iodide is a toxic metabolite of the neurotoxin MPTP, MPP+ iodide causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra.
PF670462 is a potent and selective inhibitor of of CK1 delta and epsilon (CK1δ/ε).
PF670462 is a potent and selective inhibitor of of CK1 delta and epsilon (CK1δ/ε).
Neoruscogenin is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1).