NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS).
SGA360 suppress inflammatory SAA1 signaling in an AHR-dependent manner through a mechanism that does not require AHR binding to its cognate response element (partial antagonist).
Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic agent that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic...
Butyzamide is a novel, potent, orally active activator of the non-peptidic thrombopoietin receptor (Mpl) that specifically reacts with human Mpl and activates the same signaling pathways as thrombopoietin. In addition, Butyzamide can be used for the expansion of human hematopoietic stem cells.
Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is an agonist of Protease-Activated Receptor 3 (PAR-3).
2-Ethylhexyl palmitate is a high fatty acid ester and a good solvent for coloring. It is also used as a softener and a thickener.
Loliolide, a Carotenoid Metabolite, is a potential endogenous inducer of herbivore resistance. Loliolide also inhibits the seedling growth.
BQ-3020 ammonium is an endothelin receptor ETB agonist and induces endothelium-dependent vasodilation, which can be used in studies related to cardiovascular disease.
BQ-3020 ammonium is an endothelin receptor ETB agonist and induces endothelium-dependent vasodilation, which can be used in studies related to cardiovascular disease.
KPLH1130 is a pyruvate dehydrogenase kinase (PDK)-specific inhibitor that blocks macrophage polarization, attenuates inflammatory responses, and improves glucose tolerance in mice fed a high-fat diet.