ANA-12 is a selective TrkB antagonist with Kd of 10 nM and 12 μM for the high and low affinity sites, respectively.
BX795 is a potent and specific TBK1, IKKε and PDK-1 inhibitor with IC50 of 6 nM, 41 nM and 111 nM, respectively.
Lenvatinib mesylate (E7080 mesylate), an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities.
LE135 is an effective RAR antagonist, which can selectively bind RARα (Ki is 1.4 μM) and RARβ (Ki is 220 nM), and has a higher affinity for RARβ. The LE135 is highly selective for RARγ, RXRα, RXRβ and RXRγ. LE135 is also a vitamin A acid receptor antagonist.
Amifostine trihydrate is a broad-spectrum cytoprotection agent against the DNA damaging effects of ionizing radiation.
Pamidronate disodium pentahydrate is a nitrogen-containing bisphosphonate, used to prevent osteoporosis.
Imm-h007 is an adenosine derivative that is an activator of the AMP-Activated Protein Kinase (AMPK).
Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots.
Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots.
JDTic is a kappa opioid receptor (KOR) antagonist that prevents stress-induced reinstatement of cocaine-maintained responding and has antidepressant-like effects.
JDTic is a kappa opioid receptor (KOR) antagonist that prevents stress-induced reinstatement of cocaine-maintained responding and has antidepressant-like effects.