Polygalasaponin F is an oleanane type triterpenoid saponin extracted from Polygala Japonica, which can reduce the release of inflammatory cytokine tumor necrosis factor α (TNFa). Polygalasaponin F reduces the secretion of neuroinflammatory cytokines by regulating the TLR4-PI3K/ Akt-NF-KB signaling pathway.
Lorcaserin hydrochloride is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM.
Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) and has antibacterial and anthelmintic properties along with algaecide activity.
Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase.
Dexmedetomidine is a potent and highly selective α-2 adrenergic receptor agonist with sedative effects.
TRV130 (Oliceridine) hydrochloride is a novel μ-opioid receptor (MOR) G protein-biased ligand.
Mirdametinib (PD0325901) is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM.
b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM. *The compound is unstable in solutions, freshly prepared is recommended
PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that restores mitochondrial cytochrome c oxidase subunit 1 levels, rescues impairments of mitochondrial motility and neurite outgrowth.
Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the research of ipulmonary hypertension.
WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM, Kd of 2 nM, WM-1119 is a reversible competitor of acetyl coenzyme A and inhibits MYST-catalysed histone acetylation.