Marrubiin, isolated from Marrubium vulgare, exhibits vasorelaxant and antioedematogenic activity. Marrubiin alleviates diabetic symptoms in animals.
Balsalazide is an anti-inflammatory compound used to study inflammatory bowel disease and ulcerative colitis.
Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM.
TT-10 (TAZ-K) is an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity. TT-10 can be used for the research of heart diseases accompanied by cardiomyocyte loss.
Punicalin is a hydrolyzed tannin that can be obtained from Punica granatum L. Or from the leaves of Terminalia catappa L. Punicalin is an anti-hepatitis B virus (HBV) drug with anti-inflammatory activity.
Tenacissoside H is a natural product isolated from Tenacissoside H, which has anti-tumor effect.
Salinosporamide A (NPI-0052, Marizomib) is a novel marine derived proteasome inhibitor which inhibits CT-L, C-L, and T-L proteasome activities in human erythrocyte-derived 20S proteasomes with EC50 of 3.5 nM, 430 nM, 28 nM.
Laquinimod (ABR-215062) is a new orally active immunoregulator effectively inhibits development and relapses of experimental autoimmune encephalomyelitis.
Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively.
GSK 4112 is a selective Rev-Erbα agonist with an EC50 value of 0.4 μM, which can be used to explore the function of Rev-erbα in transcriptional repression, biological regulation of circadian rhythms and metabolic pathways.